Fmoc-Cys(Trt)-2-Chlorotrityl Resin are?widely used in solid phase peptide synthesis (SPPS). They are very acid sensitive.
Cleavage is achieved using AcOH/TFE/DCM [1-6], 0.5% TFA or HFIP in DCM , or 1-5% TFA in DCM (containing 8% triisopropylsilane).
Our loaded 2-Chlorotrityl resins prevent racemization during the loading of the first amino acid (using DIPEA), and prevents the formation of diketopiperazine. This makes it very suitable for the preparation of C-terminal prolyl and cysteinyl peptides.