Cefamandole Antimicrobial Susceptibility disks
Our Antibiotic disks contain, Cefamandole (INN, also known as cephamandole) which is a second-generation broad-spectrum cephalosporin antibiotic. Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, urinary tract, and lower respiratory tract.
The chemical structure of cefamandole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase)(vitamin K supplement is recommended during therapy) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.
The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms.
- Escherichia coli: 0.12 – 400 μg/ml
- Haemophilus influenzae: 0.06 – >16 μg/ml
- Staphylococcus aureus: 0.1 – 12.5 μg/ml
Please note that these are not a universal fitting and only work in our convenient Disk Dispenser available from here