Pre-Loaded Wang Resins

Pre-Loaded Wang Resins are very commonly used as solid phase support for acid substrates in peptide synthesis.

When the substrate is linked via a benzilic ester or ether bond and the linker is attached to the resin via a phenyl ether bond, a relatively stable linkage can be achieved that can be broken using mildly acidic conditions (normally trifluoroacetic acid).

Failure to maintain the correct reaction conditions, however, can result in the formation of a reactive phenolic site.